Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death

The 24(S)-hydroxycholesterol (24S-OHC), which plays an important role in maintaining brain cholesterol homeostasis, has been shown to possess neurotoxicity. We have previously reported that 24S-OHC esterification by ACAT1 and the resulting lipid droplet (LD) formation are responsible for 24S-OHC-ind...

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Dettagli Bibliografici
Pubblicato in:J Lipid Res
Autori principali: Takabe, Wakako, Urano, Yasuomi, Vo, Diep-Khanh Ho, Shibuya, Kimiyuki, Tanno, Masaki, Kitagishi, Hiroaki, Fujimoto, Toyoshi, Noguchi, Noriko
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087868/
https://ncbi.nlm.nih.gov/pubmed/27647838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M068775
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