Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution

[Image: see text] An acyl-CoA:cholesterol O-acyltransferase-1 (ACAT-1/SOAT-1) inhibitor, K-604 is a promising drug candidate for the treatment of Alzheimer’s disease and glioblastoma; however, it exhibits poor solubility in neutral water and low permeability across the blood–brain barrier. In this s...

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Vydáno v:ACS Omega
Hlavní autoři: Shibuya, Kimiyuki, Morikawa, Shigeru, Miyamoto, Masayoshi, Ogawa, Shin-ichiro, Tsunenari, Yoshihiko, Urano, Yasuomi, Noguchi, Noriko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796924/
https://ncbi.nlm.nih.gov/pubmed/31646241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b02307
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