Synergistic Anticancer Action of Lysosomal Membrane Permeabilization and Glycolysis Inhibition

We investigated the in vitro and in vivo anticancer effect of combining lysosomal membrane permeabilization (LMP)-inducing agent N-dodecylimidazole (NDI) with glycolytic inhibitor 2-deoxy-d-glucose (2DG). NDI-triggered LMP and 2DG-mediated glycolysis block synergized in inducing rapid ATP depletion,...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kosic, Milica, Arsikin-Csordas, Katarina, Paunovic, Verica, Firestone, Raymond A., Ristic, Biljana, Mircic, Aleksandar, Petricevic, Sasa, Bosnjak, Mihajlo, Zogovic, Nevena, Mandic, Milos, Bumbasirevic, Vladimir, Trajkovic, Vladimir, Harhaji-Trajkovic, Ljubica
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087715/
https://ncbi.nlm.nih.gov/pubmed/27587392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752113
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