Targeting Glycolysis with 2-Deoxy-D-Glucose and Lysosomal Integrity with L-Leucyl-L-Leucine Methyl Ester as Antimelanoma Strategy

<b>Background/Objectives</b>: Melanoma cells enhance glycolysis and expand lysosomes to support energy metabolism, proliferation, and metastasis. However, lysosomal membrane permeabilization (LMP) causes cathepsin leakage into cytosol triggering cytotoxicity. This study investigated the antimelanoma...

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Autores principales:	Milica Kosic, Mihajlo Bosnjak, Milos Mandic, Ljubica Vucicevic, Maja Misirkic Marjanovic, Sofie Espersen Poulsen, Ljubica Harhaji-Trajkovic
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2025-10-01
Colección:	Pharmaceutics
Materias:	melanoma lysosome membrane permeabilization glycolysis 2-deoxy-D-glucose L-leucyl-L-leucine methyl ester mefloquine
Acceso en línea:	https://www.mdpi.com/1999-4923/17/10/1312
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