3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms

We investigated the effect of 3-methyladenine (3MA), a class III phosphatidylinositol 3-kinase (PI3K)-blocking autophagy inhibitor, on cancer cell death induced by simultaneous inhibition of glycolysis by 2-deoxyglucose (2DG) and mitochondrial respiration by rotenone. 2DG/rotenone reduced ATP levels...

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Dettagli Bibliografici

Autori principali:	Milica Kosic, Verica Paunovic, Biljana Ristic, Aleksandar Mircic, Mihajlo Bosnjak, Danijela Stevanovic, Tamara Kravic-Stevovic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2021-09-01
Serie:	Journal of Pharmacological Sciences
Soggetti:	3-Methyladenine Glycolysis Mitochondria Autophagy Necrosis
Accesso online:	http://www.sciencedirect.com/science/article/pii/S1347861321000591
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