Glutathione Depletion, Pentose Phosphate Pathway Activation, and Hemolysis in Erythrocytes Protecting Cancer Cells from Vitamin C-induced Oxidative Stress

The discovery that oxidized vitamin C, dehydroascorbate (DHA), can induce oxidative stress and cell death in cancer cells has rekindled interest in the use of high dose vitamin C (VC) as a cancer therapy. However, high dose VC has shown limited efficacy in clinical trials, possibly due to the decrea...

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Pubblicato in:J Biol Chem
Autori principali: Zhang, Zhuzhen Z., Lee, Eunice E., Sudderth, Jessica, Yue, Yangbo, Zia, Ayesha, Glass, Donald, Deberardinis, Ralph J., Wang, Richard C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Accelerated Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087709/
https://ncbi.nlm.nih.gov/pubmed/27660392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C116.748848
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