Molecular and biological compatibility with host alpha-synuclein influences fibril pathogenicity

The accumulation and propagation of misfolded α-Synuclein (α-Syn) is a central feature of Parkinson’s disease (PD) and other synucleinopathies. Molecular compatibility between a fibrillar seed and its native protein state is a major determinant of amyloid self-replication. We show that cross-seeded...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Rep
Hlavní autoři: Luk, Kelvin C., Covell, Dustin J., Kehm, Victoria M., Zhang, Bin, Song, Insung Y., Byrne, Matthew D., Pitkin, Rose M., Decker, Samantha C., Trojanowski, John Q., Lee, Virginia M.-Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087609/
https://ncbi.nlm.nih.gov/pubmed/27653697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.053
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky