Molecular and biological compatibility with host alpha-synuclein influences fibril pathogenicity

The accumulation and propagation of misfolded α-Synuclein (α-Syn) is a central feature of Parkinson’s disease (PD) and other synucleinopathies. Molecular compatibility between a fibrillar seed and its native protein state is a major determinant of amyloid self-replication. We show that cross-seeded...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Luk, Kelvin C., Covell, Dustin J., Kehm, Victoria M., Zhang, Bin, Song, Insung Y., Byrne, Matthew D., Pitkin, Rose M., Decker, Samantha C., Trojanowski, John Q., Lee, Virginia M.-Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087609/
https://ncbi.nlm.nih.gov/pubmed/27653697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.053
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