Endothelin-1 Mediated Induction of Extracellular Matrix Genes in Strial Marginal Cells Underlies Strial Pathology in Alport Mice

Alport syndrome, a type IV collagen disorder, manifests as glomerular disease associated with hearing loss with thickening of the glomerular and strial capillary basement membranes (SCBMs). We have identified a role for endothelin-1 (ET-1) activation of endothelin A receptors (ET(A)Rs) in glomerular...

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Udgivet i:Hear Res
Main Authors: Meehan, Daniel T., Delimont, Duane, Dufek, Brianna, Zallocchi, Marisa, Phillips, Grady, Gratton, Michael Anne, Cosgrove, Dominic
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086449/
https://ncbi.nlm.nih.gov/pubmed/27553900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heares.2016.08.003
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