RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis

Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels of extracellular matrix expression and hypoxia-related gene a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Dufek, Brianna, Meehan, Daniel T., Delimont, Duane, Wilhelm, Kevin, Samuelson, Gina, Coenen, Ross, Madison, Jacob, Doyle, Edward, Smyth, Brendan, Phillips, Grady, Gratton, Michael Anne, Cosgrove, Dominic
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446819/
https://ncbi.nlm.nih.gov/pubmed/32822386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0237907
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