RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis

Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels of extracellular matrix expression and hypoxia-related gene a...

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Publicado en:PLoS One
Autores principales: Dufek, Brianna, Meehan, Daniel T., Delimont, Duane, Wilhelm, Kevin, Samuelson, Gina, Coenen, Ross, Madison, Jacob, Doyle, Edward, Smyth, Brendan, Phillips, Grady, Gratton, Michael Anne, Cosgrove, Dominic
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446819/
https://ncbi.nlm.nih.gov/pubmed/32822386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0237907
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