A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.

Non-insulin-dependent diabetes mellitus (NIDDM) is a heterogeneous disorder characterized by hyperglycemia resulting from defects in insulin secretion and action. Recent studies have found mutations in the hepatocyte nuclear factor-4 alpha gene (HNF-4alpha) in families with maturity-onset diabetes o...

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Publicat a:	J Clin Invest
Autors principals:	Hani, E H, Suaud, L, Boutin, P, Chèvre, J C, Durand, E, Philippi, A, Demenais, F, Vionnet, N, Furuta, H, Velho, G, Bell, G I, Laine, B, Froguel, P
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Clinical Investigation 1998
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508593/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9449683/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1403
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