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A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.

Non-insulin-dependent diabetes mellitus (NIDDM) is a heterogeneous disorder characterized by hyperglycemia resulting from defects in insulin secretion and action. Recent studies have found mutations in the hepatocyte nuclear factor-4 alpha gene (HNF-4alpha) in families with maturity-onset diabetes o...

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Publicado no:J Clin Invest
Principais autores: Hani, E H, Suaud, L, Boutin, P, Chèvre, J C, Durand, E, Philippi, A, Demenais, F, Vionnet, N, Furuta, H, Velho, G, Bell, G I, Laine, B, Froguel, P
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508593/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9449683/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1403
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