Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.

The glycolytic enzyme glucokinase plays an important role in the regulation of insulin secretion and recent studies have shown that mutations in the human glucokinase gene are a common cause of an autosomal dominant form of non-insulin-dependent (type 2) diabetes mellitus (NIDDM) that has an onset o...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Gidh-Jain, M, Takeda, J, Xu, L Z, Lange, A J, Vionnet, N, Stoffel, M, Froguel, P, Velho, G, Sun, F, Cohen, D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45994/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8446612/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.5.1932
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