Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.

The glycolytic enzyme glucokinase plays an important role in the regulation of insulin secretion and recent studies have shown that mutations in the human glucokinase gene are a common cause of an autosomal dominant form of non-insulin-dependent (type 2) diabetes mellitus (NIDDM) that has an onset o...

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Detalhes bibliográficos
Main Authors: Gidh-Jain, M, Takeda, J, Xu, L Z, Lange, A J, Vionnet, N, Stoffel, M, Froguel, P, Velho, G, Sun, F, Cohen, D
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC45994/
https://ncbi.nlm.nih.gov/pubmed/8446612
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