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Picolinic Acids as β-Exosite Inhibitors of Botulinum Neurotoxin A Light Chain
In developing small-molecule inhibitors of botulinum neurotoxin serotype A light chain (BoNT/A LC), substituted picolinic acids were identified. Extensive investigation into the SAR of the picolinic acid scaffold revealed 5-(1-butyl-4-chloro-1H-indol-2-yl)picolinic acid (CBIP), which possessed low m...
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| Publicado no: | Chem Commun (Camb) |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5085802/ https://ncbi.nlm.nih.gov/pubmed/27722252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc06749b |
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