Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines.

Monocytes/macrophages are key cells in the pathogenesis of human cytomegalovirus (HCMV). Although HCMV infection in monocytes is restricted to early events of gene expression, productive infection has been demonstrated in differentiated macrophages in vitro. We examined the cellular and cytokine com...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Söderberg-Nauclér, C, Fish, K N, Nelson, J A
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508529/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9399963/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119871
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