Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines.

Monocytes/macrophages are key cells in the pathogenesis of human cytomegalovirus (HCMV). Although HCMV infection in monocytes is restricted to early events of gene expression, productive infection has been demonstrated in differentiated macrophages in vitro. We examined the cellular and cytokine com...

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Pubblicato in:J Clin Invest
Autori principali: Söderberg-Nauclér, C, Fish, K N, Nelson, J A
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 1997
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Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508529/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9399963/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119871
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