Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines.

Monocytes/macrophages are key cells in the pathogenesis of human cytomegalovirus (HCMV). Although HCMV infection in monocytes is restricted to early events of gene expression, productive infection has been demonstrated in differentiated macrophages in vitro. We examined the cellular and cytokine com...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Söderberg-Nauclér, C, Fish, K N, Nelson, J A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508529/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9399963/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119871
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