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Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines.

Monocytes/macrophages are key cells in the pathogenesis of human cytomegalovirus (HCMV). Although HCMV infection in monocytes is restricted to early events of gene expression, productive infection has been demonstrated in differentiated macrophages in vitro. We examined the cellular and cytokine com...

詳細記述

保存先:
書誌詳細
出版年:J Clin Invest
主要な著者: Söderberg-Nauclér, C, Fish, K N, Nelson, J A
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 1997
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508529/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9399963/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119871
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