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High-Accuracy HLA Type Inference from Whole-Genome Sequencing Data Using Population Reference Graphs

Genetic variation at the Human Leucocyte Antigen (HLA) genes is associated with many autoimmune and infectious disease phenotypes, is an important element of the immunological distinction between self and non-self, and shapes immune epitope repertoires. Determining the allelic state of the HLA genes...

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Pubblicato in:PLoS Comput Biol
Autori principali: Dilthey, Alexander T., Gourraud, Pierre-Antoine, Mentzer, Alexander J., Cereb, Nezih, Iqbal, Zamin, McVean, Gil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085092/
https://ncbi.nlm.nih.gov/pubmed/27792722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005151
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