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De novo assembly and genotyping of variants using colored de Bruijn graphs
Detecting genetic variants that are highly divergent from a reference sequence remains a major challenge in genome sequencing. We introduce de novo assembly algorithms using colored de Bruijn graphs for detecting and genotyping simple and complex genetic variants in an individual or population. We p...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272472/ https://ncbi.nlm.nih.gov/pubmed/22231483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.1028 |
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