Genome-wide somatic variant calling using localized colored de Bruijn graphs

Reliable detection of somatic variations is of critical importance in cancer research. Here we present Lancet, an accurate and sensitive somatic variant caller, which detects SNVs and indels by jointly analyzing reads from tumor and matched normal samples using colored de Bruijn graphs. We demonstra...

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Vydáno v:Commun Biol
Hlavní autoři: Narzisi, Giuseppe, Corvelo, André, Arora, Kanika, Bergmann, Ewa A., Shah, Minita, Musunuri, Rajeeva, Emde, Anne-Katrin, Robine, Nicolas, Vacic, Vladimir, Zody, Michael C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123722/
https://ncbi.nlm.nih.gov/pubmed/30271907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0023-9
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