Synaptopodin Limits TRPC6 Podocyte Surface Expression and Attenuates Proteinuria

Gain-of-function mutations of classic transient receptor potential channel 6 (TRPC6) were identified in familial FSGS, and increased expression of wild-type TRPC6 in glomeruli is observed in several human acquired proteinuric diseases. Synaptopodin, an actin binding protein that is important in main...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Yu, Hao, Kistler, Andreas, Faridi, Mohd Hafeez, Meyer, James Otto, Tryniszewska, Beata, Mehta, Dolly, Yue, Lixia, Dryer, Stuart, Reiser, Jochen
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2016
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084886/
https://ncbi.nlm.nih.gov/pubmed/27020855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015080896
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