inv(16) and NPM1(mut) AMLs engraft human cytokine knock-in mice

Favorable-risk human acute myeloid leukemia (AML) engrafts poorly in currently used immunodeficient mice, possibly because of insufficient environmental support of these leukemic entities. To address this limitation, we here transplanted primary human AML with isolated nucleophosmin (NPM1) mutation...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Ellegast, Jana M., Rauch, Philipp J., Kovtonyuk, Larisa V., Müller, Rouven, Wagner, Ulrich, Saito, Yasuyuki, Wildner-Verhey van Wijk, Nicole, Fritz, Christine, Rafiei, Anahita, Lysenko, Veronika, Dudkiewicz, Ewa, Theocharides, Alexandre P., Soldini, Davide, Goede, Jeroen S., Flavell, Richard A., Manz, Markus G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084606/
https://ncbi.nlm.nih.gov/pubmed/27581357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-12-689356
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