Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity.

Interleukin 1beta (IL-1beta)-induced beta cell cytotoxicity has been implicated in the autoimmune cytotoxicity of insulin-dependent diabetes mellitus. These cytotoxic effects may be mediated by nitric oxide (NO). Since long-chain fatty acids (FFA), like IL-1beta, upregulate inducible nitric oxide sy...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Shimabukuro, M, Koyama, K, Lee, Y, Unger, R H
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1997
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508358/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9312173/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119700
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