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Role of nitric oxide in obesity-induced beta cell disease.

Here we report that free fatty acid-induced suppression of insulin output in prediabetic Zucker diabetic fatty (ZDF) rats is mediated by NO. When normal islets were cultured in 2 mM FFA, NO production and basal insulin secretion increased slightly. In cultured prediabetic ZDF islets, FFA induced a f...

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Bibliografiske detaljer
Main Authors: Shimabukuro, M, Ohneda, M, Lee, Y, Unger, R H
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC508191/
https://ncbi.nlm.nih.gov/pubmed/9218505
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