B cell depletion promotes aortic infiltration of immunosuppressive cells and is protective of experimental aortic aneurysm

OBJECTIVE: B cell depletion therapy is widely used for treatment of cancers and autoimmune diseases. B cells are abundant in abdominal aortic aneurysms (AAA), however, it is unknown whether B cell depletion therapy affects AAA growth. Using experimental models of murine AAA, we aim to examine the ef...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Schaheen, Basil, Downs, Emily A., Serbulea, Vlad, Almenara, Camila C.P., Spinosa, Michael, Su, Gang, Zhao, Yunge, Srikakulapu, Prasad, Butts, Cherié, McNamara, Coleen A., Leitinger, Norbert, Upchurch, Gilbert R., Meher, Akshaya K., Ailawadi, Gorav
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083246/
https://ncbi.nlm.nih.gov/pubmed/27634836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307559
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