Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior

Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2(R306C) mutation prevents MeCP2 interaction with NCoR/Histone deacetylase 3 (HDAC3); however, the neuronal function of HDAC3 is incompletely understood. We report that neuronal deletion of Hdac3 in mi...

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Publicado en:Nat Neurosci
Main Authors: Nott, Alexi, Cheng, Jemmie, Gao, Fan, Lin, Yuan-Ta, Gjoneska, Elizabeta, Ko, Tak, Minhas, Paras, Zamudio, Alicia Viridiana, Meng, Jia, Zhang, Feiran, Jin, Peng, Tsai, Li-Huei
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083138/
https://ncbi.nlm.nih.gov/pubmed/27428650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4347
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