A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation

Amongst the many strategies aiming at inhibiting HIV-1 infection, blocking viral entry has been recently recognized as a very promising approach. Using diverse in vitro models and a broad range of HIV-1 primary patient isolates, we report here that IND02, a type A procyanidin polyphenol extracted fr...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Connell, Bridgette Janine, Chang, Sui-Yuan, Prakash, Ekambaranellore, Yousfi, Rahima, Mohan, Viswaraman, Posch, Wilfried, Wilflingseder, Doris, Moog, Christiane, Kodama, Eiichi N., Clayette, Pascal, Lortat-Jacob, Hugues
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082894/
https://ncbi.nlm.nih.gov/pubmed/27788205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165386
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