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Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells.

Nitric oxide stimulates soluble guanylate cyclase (sGC) to convert GTP to the intracellular second messenger cGMP. In rat pulmonary artery smooth muscle cells, sGC is an obligate heterodimer composed of alpha1 and beta1 subunits. We investigated the effect of NO donor compounds on sGC subunit gene e...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Filippov, G, Bloch, D B, Bloch, K D
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1997
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508267/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9259594/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119610
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