MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma

Glioblastoma multiforme (GBM) remains the deadliest malignant brain tumor, with glioma stem cells (GSCs) contributing to treatment resistance and tumor recurrence. We have identified MAPK-interacting kinases (MNKs) as potential targets for the GSC population in GBM. Isoform-level subtyping using The...

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Publié dans:Mol Cancer Res
Auteurs principaux: Bell, Jonathan B., Eckerdt, Frank, Alley, Kristen, Magnusson, Lisa P., Hussain, Hridi, Bi, Yingtao, Arslan, Ahmet Dirim, Clymer, Jessica, Alvarez, Angel A., Goldman, Stewart, Cheng, Shi-Yuan, Nakano, Ichiro, Horbinski, Craig, Davuluri, Ramana V., James, C. David, Platanias, Leonidas C.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082426/
https://ncbi.nlm.nih.gov/pubmed/27364770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0172
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