Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp70 and NF-κB Activation

Severe malarial anemia (SMA; hemoglobin [Hb] <5.0 g/dL) is a leading global cause of morbidity and mortality among children residing in Plasmodium falciparum transmission regions. Exploration of molecular pathways through global gene expression profiling revealed that SMA was characterized by dec...

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Опубликовано в: :Mol Med
Главные авторы: Kempaiah, Prakasha, Dokladny, Karol, Karim, Zachary, Raballah, Evans, Ong’echa, John M, Moseley, Pope L, Perkins, Douglas J
Формат: Artigo
Язык:Inglês
Опубликовано: Feinstein Institute for Medical Research 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082292/
https://ncbi.nlm.nih.gov/pubmed/27579474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00130
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