Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK

Dietary restriction (DR), such as calorie restriction (CR) or methionine (Met) restriction, extends the lifespan of diverse model organisms. Although studies have identified several metabolites that contribute to the beneficial effects of DR, the molecular mechanism underlying the key metabolites re...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Ogawa, Takafumi, Tsubakiyama, Ryohei, Kanai, Muneyoshi, Koyama, Tetsuya, Fujii, Tsutomu, Iefuji, Haruyuki, Soga, Tomoyoshi, Kume, Kazunori, Miyakawa, Tokichi, Hirata, Dai, Mizunuma, Masaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081624/
https://ncbi.nlm.nih.gov/pubmed/27698120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604047113
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