Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK

Dietary restriction (DR), such as calorie restriction (CR) or methionine (Met) restriction, extends the lifespan of diverse model organisms. Although studies have identified several metabolites that contribute to the beneficial effects of DR, the molecular mechanism underlying the key metabolites re...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ogawa, Takafumi, Tsubakiyama, Ryohei, Kanai, Muneyoshi, Koyama, Tetsuya, Fujii, Tsutomu, Iefuji, Haruyuki, Soga, Tomoyoshi, Kume, Kazunori, Miyakawa, Tokichi, Hirata, Dai, Mizunuma, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081624/
https://ncbi.nlm.nih.gov/pubmed/27698120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604047113
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