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Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan
Methionine restriction extends the lifespan of various model organisms. Limiting S-adenosyl-methionine (SAM) synthesis, the first metabolic reaction of dietary methionine, extends longevity in Caenorhabditis elegans but accelerates pathology in mammals. Here, we show that, as an alternative to inhib...
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Publicado no: | Nat Commun |
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Main Authors: | , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Pub. Group
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4595730/ https://ncbi.nlm.nih.gov/pubmed/26383889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9332 |
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