Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism

Oligodendrocytes have recently been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). Here we show that, in vitro, mutant superoxide dismutase 1 (SOD1) mouse oligodendrocytes induce WT motor neuron (MN) hyperexcitability and death. Moreover, we efficiently derived human oligo...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Ferraiuolo, Laura, Meyer, Kathrin, Sherwood, Thomas W., Vick, Jonathan, Likhite, Shibi, Frakes, Ashley, Miranda, Carlos J., Braun, Lyndsey, Heath, Paul R., Pineda, Ricardo, Beattie, Christine E., Shaw, Pamela J., Askwith, Candice C., McTigue, Dana, Kaspar, Brian K.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081600/
https://ncbi.nlm.nih.gov/pubmed/27688759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607496113
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