Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism

Oligodendrocytes have recently been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). Here we show that, in vitro, mutant superoxide dismutase 1 (SOD1) mouse oligodendrocytes induce WT motor neuron (MN) hyperexcitability and death. Moreover, we efficiently derived human oligo...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Ferraiuolo, Laura, Meyer, Kathrin, Sherwood, Thomas W., Vick, Jonathan, Likhite, Shibi, Frakes, Ashley, Miranda, Carlos J., Braun, Lyndsey, Heath, Paul R., Pineda, Ricardo, Beattie, Christine E., Shaw, Pamela J., Askwith, Candice C., McTigue, Dana, Kaspar, Brian K.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2016
主題:
PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081600/
https://ncbi.nlm.nih.gov/pubmed/27688759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607496113
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