Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3

Amyloid-β (Aβ) is a prime suspect for causing cognitive deficits during the early phases of Alzheimer’s disease (AD). Experiments in AD mouse models have shown that soluble oligomeric clusters of Aβ degrade synapses and impair memory formation. We show that all Aβ-driven effects measured in these mi...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Reinders, Niels R., Pao, Yvonne, Renner, Maria C., da Silva-Matos, Carla M., Lodder, Tessa R., Malinow, Roberto, Kessels, Helmut W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081598/
https://ncbi.nlm.nih.gov/pubmed/27708157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614249113
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