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Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3

Amyloid-β (Aβ) is a prime suspect for causing cognitive deficits during the early phases of Alzheimer’s disease (AD). Experiments in AD mouse models have shown that soluble oligomeric clusters of Aβ degrade synapses and impair memory formation. We show that all Aβ-driven effects measured in these mi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Reinders, Niels R., Pao, Yvonne, Renner, Maria C., da Silva-Matos, Carla M., Lodder, Tessa R., Malinow, Roberto, Kessels, Helmut W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081598/
https://ncbi.nlm.nih.gov/pubmed/27708157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614249113
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