Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3

Amyloid-β (Aβ) is a prime suspect for causing cognitive deficits during the early phases of Alzheimer’s disease (AD). Experiments in AD mouse models have shown that soluble oligomeric clusters of Aβ degrade synapses and impair memory formation. We show that all Aβ-driven effects measured in these mi...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Reinders, Niels R., Pao, Yvonne, Renner, Maria C., da Silva-Matos, Carla M., Lodder, Tessa R., Malinow, Roberto, Kessels, Helmut W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081598/
https://ncbi.nlm.nih.gov/pubmed/27708157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614249113
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