Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition

Transcriptional enhancers control cell-type–specific gene expression. Primed enhancers are marked by histone H3 lysine 4 (H3K4) mono/di-methylation (H3K4me1/2). Active enhancers are further marked by H3K27 acetylation (H3K27ac). Mixed-lineage leukemia 4 (MLL4/KMT2D) is a major enhancer H3K4me1/2 met...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Wang, Chaochen, Lee, Ji-Eun, Lai, Binbin, Macfarlan, Todd S., Xu, Shiliyang, Zhuang, Lenan, Liu, Chengyu, Peng, Weiqun, Ge, Kai
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081576/
https://ncbi.nlm.nih.gov/pubmed/27698142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606857113
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