Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells

In both mice and humans, pluripotent stem cells (PSCs) exist in at least two distinct states of pluripotency, known as the naïve and primed states. Our understanding of the intrinsic and extrinsic factors that enable PSCs to self-renew and to transition between different pluripotent states is import...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Xu, Zhuojin, Robitaille, Aaron M., Berndt, Jason D., Davidson, Kathryn C., Fischer, Karin A., Mathieu, Julie, Potter, Jennifer C., Ruohola-Baker, Hannele, Moon, Randall T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081574/
https://ncbi.nlm.nih.gov/pubmed/27698112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613849113
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