Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4

Signal transduction pathways play diverse, context-dependent roles in vertebrate development. In studies of human embryonic stem cells (hESCs), conflicting reports claim Wnt/β-catenin signaling promotes either self-renewal or differentiation. We use a sensitive reporter to establish that Wnt/β-caten...

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Bibliographic Details
Main Authors: Davidson, Kathryn C., Adams, Allison M., Goodson, Jamie M., McDonald, Circe E., Potter, Jennifer C., Berndt, Jason D., Biechele, Travis L., Taylor, Russell J., Moon, Randall T.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311359/
https://ncbi.nlm.nih.gov/pubmed/22392999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118777109
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