The metabolome regulates the epigenetic landscape during naïve to primed human embryonic stem cell transition

For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types. Recently, it has been recognized that embryonic stem cells derived from both mice and humans display two stable yet epigenetically distinct s...

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Udgivet i:Nat Cell Biol
Main Authors: Sperber, Henrik, Mathieu, Julie, Wang, Yuliang, Ferreccio, Amy, Hesson, Jennifer, Xu, Zhuojin, Fischer, Karin A., Devi, Arikketh, Detraux, Damien, Gu, Haiwei, Battle, Stephanie L., Showalter, Megan, Valensisi, Cristina, Bielas, Jason H., Ericson, Nolan G., Margaretha, Lilyana, Robitaille, Aaron M., Margineantu, Daciana, Fiehn, Oliver, Hockenbery, David, Blau, C. Anthony, Raftery, Daniel, Margolin, Adam, Hawkins, R. David, Moon, Randall T., Ware, Carol B., Ruohola-Baker, Hannele
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662931/
https://ncbi.nlm.nih.gov/pubmed/26571212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3264
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