Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABA(A) Receptor γ2 Subunit in the Cerebellum

Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABA(A) receptors. In recombinant receptors and genetic mouse models their actions depend on the α, β, and δ subunits of the receptor, especially on those that form extrasynaptic GABA(A)...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Leppä, Elli, Linden, Anni-Maija, Aller, Maria I., Wulff, Peer, Vekovischeva, Olga, Luscher, Bernhard, Lüddens, Hartmut, Wisden, William, Korpi, Esa R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081378/
https://ncbi.nlm.nih.gov/pubmed/27833556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00403
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