Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABA(A) Receptor γ2 Subunit in the Cerebellum

Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABA(A) receptors. In recombinant receptors and genetic mouse models their actions depend on the α, β, and δ subunits of the receptor, especially on those that form extrasynaptic GABA(A)...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Leppä, Elli, Linden, Anni-Maija, Aller, Maria I., Wulff, Peer, Vekovischeva, Olga, Luscher, Bernhard, Lüddens, Hartmut, Wisden, William, Korpi, Esa R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081378/
https://ncbi.nlm.nih.gov/pubmed/27833556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00403
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