Very low-depth sequencing in a founder population identifies a cardioprotective APOC3 signal missed by genome-wide imputation

Cohort-wide very low-depth whole-genome sequencing (WGS) can comprehensively capture low-frequency sequence variation for the cost of a dense genome-wide genotyping array. Here, we analyse 1x sequence data across the APOC3 gene in a founder population from the island of Crete in Greece (n = 1239) an...

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Bibliografiske detaljer
Udgivet i:Hum Mol Genet
Main Authors: Gilly, Arthur, Ritchie, Graham Rs, Southam, Lorraine, Farmaki, Aliki-Eleni, Tsafantakis, Emmanouil, Dedoussis, George, Zeggini, Eleftheria
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Association Studies Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081052/
https://ncbi.nlm.nih.gov/pubmed/27146844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw088
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