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Very low-depth sequencing in a founder population identifies a cardioprotective APOC3 signal missed by genome-wide imputation
Cohort-wide very low-depth whole-genome sequencing (WGS) can comprehensively capture low-frequency sequence variation for the cost of a dense genome-wide genotyping array. Here, we analyse 1x sequence data across the APOC3 gene in a founder population from the island of Crete in Greece (n = 1239) an...
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| Foilsithe in: | Hum Mol Genet |
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| Main Authors: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Oxford University Press
2016
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5081052/ https://ncbi.nlm.nih.gov/pubmed/27146844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw088 |
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