Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo.

Coagulation proteases were tested in a rat model of acute inflammation. Subplantar injection of Factor Xa (10-30 microg) produced a time- and dose-dependent edema in the rat paw, and potentiated carrageenin-induced edema. In contrast, the homologous protease Factor IXa was ineffective. This inflamma...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Cirino, G, Cicala, C, Bucci, M, Sorrentino, L, Ambrosini, G, DeDominicis, G, Altieri, D C
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508085/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9153288/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119428
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