The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA

Andes virus (ANDV) predominantly infects microvascular endothelial cells (MECs) and nonlytically causes an acute pulmonary edema termed hantavirus pulmonary syndrome (HPS). In HPS patients, virtually every pulmonary MEC is infected, MECs are enlarged, and infection results in vascular leakage and hi...

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Udgivet i:mBio
Main Authors: Gorbunova, Elena E., Simons, Matthew J., Gavrilovskaya, Irina N., Mackow, Erich R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080385/
https://ncbi.nlm.nih.gov/pubmed/27795403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01747-16
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