Conversion of the major birch pollen allergen, Bet v 1, into two nonanaphylactic T cell epitope-containing fragments: candidates for a novel form of specific immunotherapy.

A novel approach to reduce the anaphylactic activity of allergens is suggested. The strategy makes use of the presence of conformational immunoglobulin E (IgE) epitopes on one of the most common allergens. The three dimensional structure of the major birch pollen allergen, Bet v 1, was disrupted by...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Vrtala, S, Hirtenlehner, K, Vangelista, L, Pastore, A, Eichler, H G, Sperr, W R, Valent, P, Ebner, C, Kraft, D, Valenta, R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 1997
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507987/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9120011/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119330
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